Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL683427

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against Fatty-acid amide hydrolase (FAAH) at pH 9.0
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Fatty-acid amide hydrolase 1 (CHEMBL2243)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase.
Patricelli MP, Patterson JE, Boger DL, Cravatt BF.
Bioorg Med Chem Lett (1998) 8 : 613 -618
PubMed 9871570 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.83 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414450 1 6.22
CHEMBL422064 1 6.22
CHEMBL157736 1 6.00
CHEMBL155928 1 5.82
CHEMBL347894 1 5.58
CHEMBL345382 1 5.54
CHEMBL157232 1 5.40
CHEMBL156529 1 -
CHEMBL157781 1 -
CHEMBL421995 1 -
CHEMBL157196 1 -
CHEMBL352250 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414450 IC50 = 600.0 nM 6.22
CHEMBL422064 IC50 = 600.0 nM 6.22
CHEMBL157736 IC50 = 1000.0 nM 6.00
CHEMBL155928 IC50 = 1500.0 nM 5.82
CHEMBL347894 IC50 = 2600.0 nM 5.58
CHEMBL345382 IC50 = 2900.0 nM 5.54
CHEMBL157232 IC50 = 4000.0 nM 5.40
CHEMBL156529 IC50 > 100000.0 nM -
CHEMBL157781 IC50 > 100000.0 nM -
CHEMBL421995 IC50 > 100000.0 nM -
CHEMBL157196 IC50 > 100000.0 nM -
CHEMBL352250 IC50 > 100000.0 nM -