Compound Detail
CHEMBL345382
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Basic Information
| ChEMBL ID | CHEMBL345382 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HUHIEWBFVDURRY-SNVBAGLBSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
248.8
MW (Da)
3.09
ALogP
3
HBA
0
HBD
43.4
PSA (Ų)
0.27
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.16
Ki 1 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 6.16 | 5.85 | 700.0 | 2 |
| Fatty-acid amide hydrolase 1 CHEMBL2243 | Ki | 5.96 | 5.96 | 1100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 700.0 | nM | 6.16 | Concentration required to inhibit fatty acid amide hydrolase (FAAH) at pH 7.0 | 9871570 |
| Fatty-acid amide hydrolase 1 | Ki | = | 1100.0 | nM | 5.96 | Compound was tested for inhibitory potency against Fatty-acid amide hydrolase (F... | 9871570 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 2900.0 | nM | 5.54 | Inhibitory concentration against Fatty-acid amide hydrolase (FAAH) at pH 9.0 | 9871570 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9871570 | 10.1016/s0960-894x(98)00073-0 | Fatty-acid amide hydrolase 1 | 3 |
Data from ChEMBL 36 via Core Engine