Compound Detail
CHEMBL157232
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Basic Information
| ChEMBL ID | CHEMBL157232 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XYVHUTVZCCRZPW-JTQLQIEISA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
293.2
MW (Da)
3.24
ALogP
3
HBA
0
HBD
43.4
PSA (Ų)
0.28
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.4
Ki 1 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | Ki | 5.96 | 5.96 | 1100.0 | 1 |
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 5.4 | 5.4 | 4000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | Ki | = | 1100.0 | nM | 5.96 | Compound was tested for inhibitory potency against Fatty-acid amide hydrolase (F... | 9871570 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 4000.0 | nM | 5.4 | Inhibitory concentration against Fatty-acid amide hydrolase (FAAH) at pH 9.0 | 9871570 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9871570 | 10.1016/s0960-894x(98)00073-0 | Fatty-acid amide hydrolase 1 | 2 |
Data from ChEMBL 36 via Core Engine