Assay Detail
Functional
CHEMBL683611
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Opioid agonistic activity was measured in guinea pig ileum
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Some 14 beta-substituted analogues of N-(cyclopropylmethyl)normorphine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.65 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69636 | — | — | 1 | 8.67 |
| CHEMBL415284 | NALORPHINE | 2.0 | 1 | 7.61 |
| CHEMBL66872 | — | — | 1 | 7.41 |
| CHEMBL68715 | — | — | 1 | 7.38 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69636 | — | IC50 | = | 2.16 | nM | 8.67 |
| CHEMBL415284 | NALORPHINE | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL66872 | — | IC50 | = | 39.1 | nM | 7.41 |
| CHEMBL68715 | — | IC50 | = | 41.2 | nM | 7.38 |
| CHEMBL70 | MORPHINE | IC50 | = | 68.2 | nM | 7.17 |