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Compound Detail

CHEMBL68715

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O=C1C=C[C@@]2([N+](=O)[O-])C3Cc4ccc(O)c5c4C2(CCN3CC2CC2)[C@H]1O5

Basic Information

ChEMBL ID CHEMBL68715
Phase Preclinical
Structure Type MOL
InChI Key JXCTWWBMCITXIY-FOCMDNRUSA-N
2
Targets
3
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names

Molecular Properties

368.4
MW (Da)
1.59
ALogP
6
HBA
1
HBD
92.9
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H20N2O5
MW 368.39
Aromatic Rings 1
Heavy Atoms 27
NP-Likeness 1.18

Activity Summary

IC50 3 meas. best 7.38

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cavia porcellus
CHEMBL369
IC50 7.38 7.38 41.2 1
Mus musculus
CHEMBL375
IC50 6.48 6.36 330.0 2

Pharmacokinetic Data

Parameter Value Units Species
Ke 4.44 nM Cavia porcellus
Ke 14.9 nM Mus musculus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
7205890 10.1021/jm00134a018 Mus musculus 3
7205890 10.1021/jm00134a018 Cavia porcellus 1
7205890 10.1021/jm00134a018 Opioid receptors; mu & kappa 1

Data from ChEMBL 36 via Core Engine