Assay Detail
Functional
CHEMBL684405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for hypotensive activity against guinea pig detrusor (bladder) strip mildly depolarized with 15 mM KCl
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anilide tertiary carbinols: A new structural class of potent potassium channel openers
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.16 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93954 | — | — | 1 | 7.16 |
| CHEMBL11684 | (-)-CROMAKALIM | — | 1 | 6.24 |
| CHEMBL343195 | — | — | 1 | 5.80 |
| CHEMBL92840 | — | — | 1 | 5.42 |
| CHEMBL356671 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93954 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL11684 | (-)-CROMAKALIM | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL343195 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL92840 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL356671 | — | IC50 | > | 30000.0 | nM | - |