Compound Detail
CHEMBL92840
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Basic Information
| ChEMBL ID | CHEMBL92840 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GNVWYNKNTYVESS-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
374.3
MW (Da)
2.17
ALogP
5
HBA
2
HBD
96.4
PSA (Ų)
0.86
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptors; K-ATP channels CHEMBL2095152 | IC50 | 6.27 | 5.92 | 540.0 | 2 |
| Cavia porcellus CHEMBL369 | IC50 | 5.42 | 5.42 | 3800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptors; K-ATP channels | IC50 | = | 540.0 | nM | 6.27 | Contraction and relaxation of guinea pig portal vein with KCl and glibenclamide ... | 8917648 |
| Sulfonylurea receptors; K-ATP channels | IC50 | = | 2700.0 | nM | 5.57 | IC50 evaluated by measuring contraction and relaxation of guinea pig bladder str... | 8917648 |
| Cavia porcellus | IC50 | = | 3800.0 | nM | 5.42 | The compound was tested for hypotensive activity against guinea pig detrusor (bl... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8917648 | 10.1021/jm960365n | Rattus norvegicus | 9 |
| 8917648 | 10.1021/jm960365n | Sulfonylurea receptors; K-ATP channels | 2 |
| 8917648 | 10.1021/jm960365n | No relevant target | 1 |
| - | 10.1016/S0960-894X(01)80750-2 | Cavia porcellus | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine