Assay Detail
Functional
CHEMBL684534
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its agonist potency by measurement of potentiation of 2-chloroadenosine stimulation of cyclic AMP accumulation in guinea pig cerebral cortical synaptoneurosomal preparations.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and adrenergic activity of ring-fluorinated phenylephrines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.71 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61372 | — | — | 1 | 5.40 |
| CHEMBL1215 | PHENYLEPHRINE | 4.0 | 1 | 4.58 |
| CHEMBL62072 | — | — | 1 | 4.46 |
| CHEMBL302451 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61372 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1215 | PHENYLEPHRINE | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL62072 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL302451 | — | EC50 | = | 40000.0 | nM | 4.40 |