Assay Detail
Functional
CHEMBL684548
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Concentration that elicits 50% of its own maximum contractile response in guinea pig urinary bladder
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Urinary bladder |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.48 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 9.05 |
| CHEMBL51215 | — | — | 1 | 8.70 |
| CHEMBL157875 | — | — | 1 | 8.34 |
| CHEMBL48269 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14 | CARBACHOL | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL51215 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL157875 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL48269 | — | EC50 | = | 15.0 | nM | 7.82 |