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Compound Detail

CHEMBL51215

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CC1CCC(=O)N1CC#CC[N+](C)(C)C.[I-]

Basic Information

ChEMBL ID CHEMBL51215
Phase Preclinical
Structure Type MOL
InChI Key QQXGIHDPMVPWDQ-UHFFFAOYSA-M
Parent Compound CHEMBL154778
Active Moiety CHEMBL154778
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

209.3
MW (Da)
0.71
ALogP
1
HBA
0
HBD
20.3
PSA (Ų)
0.48
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H21IN2O
MW 336.22
Aromatic Rings 0
Heavy Atoms 15
NP-Likeness -0.23

Activity Summary

EC50 2 meas. best 9.74
Kd 2 meas. best 5.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cavia porcellus
CHEMBL369
EC50 9.74 9.22 0.2 2
Cavia porcellus
CHEMBL369
Kd 5.77 5.66 1700.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
3346881 10.1021/jm00398a031 Cavia porcellus 8
3346881 10.1021/jm00398a031 Mus musculus 5

Data from ChEMBL 36 via Core Engine