Assay Detail
Functional
CHEMBL686997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Equilibrium dissociation constant receptor complex, measured in guinea pig urinary bladder
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 5.64 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310852 | — | — | 1 | 6.85 |
| CHEMBL157875 | — | — | 1 | 6.24 |
| CHEMBL354923 | — | — | 1 | 5.68 |
| CHEMBL157815 | — | — | 1 | 5.60 |
| CHEMBL51215 | — | — | 1 | 5.55 |
| CHEMBL157816 | — | — | 1 | 5.46 |
| CHEMBL48269 | — | — | 1 | 4.93 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310852 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL157875 | — | Kd | = | 580.0 | nM | 6.24 |
| CHEMBL354923 | — | Kd | = | 2100.0 | nM | 5.68 |
| CHEMBL157815 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL51215 | — | Kd | = | 2800.0 | nM | 5.55 |
| CHEMBL157816 | — | Kd | = | 3500.0 | nM | 5.46 |
| CHEMBL48269 | — | Kd | = | 11800.0 | nM | 4.93 |
| CHEMBL14 | CARBACHOL | Kd | = | 17000.0 | nM | 4.77 |