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Compound Detail

CHEMBL157816

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CC[N+](C)(C)CC#CCN1C(=O)CCC1C.[I-]

Basic Information

ChEMBL ID CHEMBL157816
Phase Preclinical
Structure Type MOL
InChI Key RFUBXIOWFAWDGY-UHFFFAOYSA-M
Parent Compound CHEMBL1181167
Active Moiety CHEMBL1181167
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

223.3
MW (Da)
1.10
ALogP
1
HBA
0
HBD
20.3
PSA (Ų)
0.52
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H23IN2O
MW 350.24
Aromatic Rings 0
Heavy Atoms 16
NP-Likeness -0.32

Activity Summary

Kd 2 meas. best 5.46
EC50 1 meas. best 8.49

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cavia porcellus
CHEMBL369
EC50 8.49 8.49 3.2 1
Cavia porcellus
CHEMBL369
Kd 5.46 5.385 3500.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
3346881 10.1021/jm00398a031 Cavia porcellus 6
3346881 10.1021/jm00398a031 Mus musculus 2

Data from ChEMBL 36 via Core Engine