Assay Detail
Functional
CHEMBL686996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Equilibrium dissociation constant receptor complex, measured in guinea pig ileum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 5.74 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310852 | — | — | 1 | 6.62 |
| CHEMBL157875 | — | — | 1 | 6.28 |
| CHEMBL354923 | — | — | 1 | 5.96 |
| CHEMBL51215 | — | — | 1 | 5.77 |
| CHEMBL157815 | — | — | 1 | 5.75 |
| CHEMBL48269 | — | — | 1 | 5.37 |
| CHEMBL157816 | — | — | 1 | 5.31 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310852 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL157875 | — | Kd | = | 520.0 | nM | 6.28 |
| CHEMBL354923 | — | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL51215 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL157815 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL48269 | — | Kd | = | 4300.0 | nM | 5.37 |
| CHEMBL157816 | — | Kd | = | 4900.0 | nM | 5.31 |
| CHEMBL14 | CARBACHOL | Kd | = | 14100.0 | nM | 4.85 |