Assay Detail
Functional
CHEMBL684547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration that elicits 50% of its own maximum contractile response in guinea pig ileum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 9.43 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 9.96 |
| CHEMBL51215 | — | — | 1 | 9.74 |
| CHEMBL310852 | — | — | 1 | 9.72 |
| CHEMBL157875 | — | — | 1 | 9.64 |
| CHEMBL48269 | — | — | 1 | 9.04 |
| CHEMBL157816 | — | — | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14 | CARBACHOL | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL51215 | — | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL310852 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL157875 | — | EC50 | = | 0.23 | nM | 9.64 |
| CHEMBL48269 | — | EC50 | = | 0.91 | nM | 9.04 |
| CHEMBL157816 | — | EC50 | = | 3.2 | nM | 8.49 |