Assay Detail
Functional
CHEMBL686659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the antagonistic activity on guinea pig ileum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.82 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26932 | — | — | 1 | 4.82 |
| CHEMBL28033 | — | — | 1 | - |
| CHEMBL278618 | — | — | 1 | - |
| CHEMBL284208 | — | — | 1 | - |
| CHEMBL285803 | — | — | 1 | - |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26932 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL28033 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL278618 | — | IC50 | > | 400.0 | nM | - |
| CHEMBL284208 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL285803 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL7303 | ARECOLINE | IC50 | > | 1000.0 | nM | - |