Compound Detail
CHEMBL26932
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL26932 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YSCXRRGPFXTFLP-UHFFFAOYSA-M |
| Parent Compound | CHEMBL1178406 |
| Active Moiety | CHEMBL1178406 |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
200.3
MW (Da)
1.38
ALogP
3
HBA
0
HBD
35.3
PSA (Ų)
0.68
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor CHEMBL1907609 | IC50 | 6.64 | 6.64 | 230.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL276 | IC50 | 6.28 | 6.28 | 530.0 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL309 | IC50 | 5.34 | 5.325 | 4600.0 | 2 |
| Cavia porcellus CHEMBL369 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor | IC50 | = | 230.0 | nM | 6.64 | Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetyl... | 3385727 |
| Muscarinic acetylcholine receptor M1 | IC50 | = | 530.0 | nM | 6.28 | Inhibition of [3H]pirenzepine binding to rat brain membrane Muscarinic acetylcho... | 3385727 |
| Muscarinic acetylcholine receptor M2 | IC50 | = | 4600.0 | nM | 5.34 | Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to... | 3385727 |
| Muscarinic acetylcholine receptor M2 | IC50 | = | 4900.0 | nM | 5.31 | Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine re... | 3385727 |
| Cavia porcellus | IC50 | = | 15000.0 | nM | 4.82 | Compound was tested for the antagonistic activity on guinea pig ileum | 3385727 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3385727 | 10.1021/jm00402a010 | Muscarinic acetylcholine receptor M2 | 2 |
| 3385727 | 10.1021/jm00402a010 | Cavia porcellus | 2 |
| 3385727 | 10.1021/jm00402a010 | Unchecked | 2 |
| 3385727 | 10.1021/jm00402a010 | Muscarinic acetylcholine receptor M1 | 1 |
| 3385727 | 10.1021/jm00402a010 | Muscarinic acetylcholine receptor | 1 |
Data from ChEMBL 36 via Core Engine