Assay Detail
Binding
CHEMBL747406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.74 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540136 | SULFOARECOLINE IODIDE | — | 1 | 8.85 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 8.72 |
| CHEMBL284208 | — | — | 1 | 8.48 |
| CHEMBL541666 | — | — | 1 | 8.04 |
| CHEMBL278618 | — | — | 1 | 7.72 |
| CHEMBL27384 | — | — | 1 | 7.55 |
| CHEMBL28033 | — | — | 1 | 7.41 |
| CHEMBL25649 | — | — | 1 | 7.37 |
| CHEMBL285803 | — | — | 1 | 6.66 |
| CHEMBL26932 | — | — | 1 | 6.64 |
| CHEMBL283834 | — | — | 1 | - |
| CHEMBL418022 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540136 | SULFOARECOLINE IODIDE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL284208 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL541666 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL278618 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL27384 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL28033 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL25649 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL285803 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL26932 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL283834 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL418022 | — | IC50 | > | 1000000.0 | nM | - |