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Compound Detail

CHEMBL540136

SULFOARECOLINE IODIDE
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COC(=O)C1=CCC[S+](C)C1.[I-]

Basic Information

ChEMBL ID CHEMBL540136
Name SULFOARECOLINE IODIDE
Phase Preclinical
Structure Type MOL
InChI Key QFIUNAPEEKPWNB-UHFFFAOYSA-M
Parent Compound CHEMBL27096
Active Moiety CHEMBL27096
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

173.3
MW (Da)
0.74
ALogP
2
HBA
0
HBD
26.3
PSA (Ų)
0.43
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H13IO2S
MW 300.16
Aromatic Rings 0
Heavy Atoms 11
NP-Likeness 0.64

Activity Summary

IC50 4 meas. best 8.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 8.85 8.85 1.4 1
Muscarinic acetylcholine receptor M2
CHEMBL309
IC50 5.6 5.035 2500.0 2
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 5.58 5.58 2600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
3385727 10.1021/jm00402a010 Muscarinic acetylcholine receptor M2 2
3385727 10.1021/jm00402a010 Cavia porcellus 2
3385727 10.1021/jm00402a010 Unchecked 2
3385727 10.1021/jm00402a010 Muscarinic acetylcholine receptor M1 1
3385727 10.1021/jm00402a010 Muscarinic acetylcholine receptor 1

Data from ChEMBL 36 via Core Engine