Assay Detail
Functional
CHEMBL687452
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Calcium antagonist potency on K+ depolarized guinea pig aortic strips
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro cardiovascular activity of 4-aryl-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,4]benzothiazin-1-ones and 7-acetoxy-6-phenyl-7a,8,9,10-tetrahydropyrrolo [2,1,-d][1,5]benzothiazepin-10-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.89 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 5.58 |
| CHEMBL21575 | — | — | 1 | 4.78 |
| CHEMBL21906 | — | — | 1 | 4.70 |
| CHEMBL282448 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL21575 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL21906 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL282448 | — | IC50 | = | 32400.0 | nM | 4.49 |