Assay Detail
Functional
CHEMBL687952
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested In vitro for the ability to inhibit electrically induced contractions of the guinea pig ileum
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.46 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084309 | — | — | 1 | 7.88 |
| CHEMBL3037874 | — | — | 1 | 7.86 |
| CHEMBL2370370 | — | — | 1 | 7.40 |
| CHEMBL2370368 | — | — | 1 | 7.17 |
| CHEMBL2370366 | — | — | 1 | 6.67 |
| CHEMBL8234 | ENKEPHALIN | — | 1 | 6.61 |
| CHEMBL2370362 | — | — | 1 | 5.87 |
| CHEMBL2370369 | — | — | 2 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084309 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL3037874 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL2370370 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2370368 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2370366 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL8234 | ENKEPHALIN | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL2370362 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL2370369 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL2370369 | — | IC50 | = | 70900.0 | nM | 4.15 |