Assay Detail
Functional
CHEMBL688542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for the calcium antagonistic activity on K+-depolarized guinea pig aortic strips
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrrolo[2,1-c][1,4]benzothiazines: synthesis, structure-activity relationships, molecular modeling studies, and cardiovascular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.02 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 5.58 |
| CHEMBL139134 | — | — | 1 | 4.78 |
| CHEMBL139748 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL139134 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL139748 | — | IC50 | = | 20000.0 | nM | 4.70 |