Assay Detail
Functional
CHEMBL689698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory effect on the spasmogen-contracted guinea pig tracheal strips in presence of acetylcholine
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.29 | 4.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130453 | — | — | 1 | 4.34 |
| CHEMBL335687 | — | — | 1 | 4.24 |
| CHEMBL1370561 | AMINOPHYLLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130453 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL335687 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL1370561 | AMINOPHYLLINE | IC50 | = | 300000.0 | nM | - |