Assay Detail
Functional
CHEMBL690656
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Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 min
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| In vivo duration | 10 | - | - |
| Kd | 1 | 7.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31025 | — | — | 1 | 7.00 |
| CHEMBL13284 | — | — | 1 | - |
| CHEMBL31608 | — | — | 1 | - |
| CHEMBL768 | ESMOLOL | 4.0 | 1 | - |
| CHEMBL30292 | — | — | 1 | - |
| CHEMBL30899 | — | — | 1 | - |
| CHEMBL286894 | — | — | 1 | - |
| CHEMBL13504 | — | — | 1 | - |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | - |
| CHEMBL6995 | PRACTOLOL | 4.0 | 1 | - |
| CHEMBL13365 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31025 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL13284 | — | In vivo duration | = | 15.0 | Minutes | - |
| CHEMBL31608 | — | In vivo duration | = | 56.0 | Minutes | - |
| CHEMBL768 | ESMOLOL | In vivo duration | = | 12.0 | Minutes | - |
| CHEMBL30292 | — | In vivo duration | = | 20.0 | Minutes | - |
| CHEMBL30899 | — | In vivo duration | = | 22.0 | Minutes | - |
| CHEMBL286894 | — | In vivo duration | = | 40.0 | Minutes | - |
| CHEMBL13504 | — | In vivo duration | = | 31.0 | Minutes | - |
| CHEMBL27 | PROPRANOLOL | In vivo duration | = | 46.0 | Minutes | - |
| CHEMBL6995 | PRACTOLOL | In vivo duration | = | 61.0 | Minutes | - |
| CHEMBL13365 | — | In vivo duration | = | 12.0 | Minutes | - |