Assay Detail
Functional
CHEMBL691385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 (IIIB) in CEM (human leukemia) cells.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 5.66 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342983 | — | — | 1 | 6.37 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.92 |
| CHEMBL298845 | — | — | 1 | 5.52 |
| CHEMBL149174 | — | — | 1 | 5.51 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 5.48 |
| CHEMBL147814 | — | — | 1 | 5.14 |
| CHEMBL346387 | — | — | 1 | - |
| CHEMBL356695 | — | — | 1 | - |
| CHEMBL356437 | — | — | 1 | - |
| CHEMBL146699 | — | — | 1 | - |
| CHEMBL150124 | — | — | 1 | - |
| CHEMBL149116 | — | — | 1 | - |
| CHEMBL149197 | — | — | 1 | - |
| CHEMBL356135 | — | — | 1 | - |
| CHEMBL149664 | — | — | 1 | - |
| CHEMBL150057 | — | — | 1 | - |
| CHEMBL348215 | — | — | 1 | - |
| CHEMBL146197 | — | — | 1 | - |
| CHEMBL148304 | — | — | 1 | - |
| CHEMBL146182 | — | — | 1 | - |
| CHEMBL358153 | — | — | 1 | - |
| CHEMBL148716 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342983 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL298845 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL149174 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL147814 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL346387 | — | EC50 | > | 14000.0 | nM | - |
| CHEMBL356695 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL356437 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL146699 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL150124 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL149116 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL149197 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL356135 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL149664 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL150057 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL348215 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL146197 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL148304 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL146182 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL358153 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL148716 | — | EC50 | > | 300000.0 | nM | - |