Assay Detail
Functional
CHEMBL692806
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of electrically evoked contractions of the guinea pig ileum (GPI)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.10 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15100 | — | — | 1 | 8.67 |
| CHEMBL280264 | — | — | 1 | 7.93 |
| CHEMBL2370199 | — | — | 1 | 7.87 |
| CHEMBL278891 | — | — | 1 | 7.83 |
| CHEMBL14887 | — | — | 1 | 7.56 |
| CHEMBL8234 | ENKEPHALIN | — | 1 | 6.61 |
| CHEMBL278889 | — | — | 1 | 6.45 |
| CHEMBL275670 | — | — | 1 | 6.42 |
| CHEMBL2370207 | — | — | 1 | 5.91 |
| CHEMBL557035 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15100 | — | IC50 | = | 2.14 | nM | 8.67 |
| CHEMBL280264 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL2370199 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL278891 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL14887 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL8234 | ENKEPHALIN | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL278889 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL275670 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL2370207 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL557035 | — | IC50 | = | 1700.0 | nM | 5.77 |