Assay Detail
Functional
CHEMBL696074
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Determined for potency (muscarinic agonistic activity) expressed in guinea pig ileum in vitro
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and characterization of all four isomers of the muscarinic agonist 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.71 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 6.99 |
| CHEMBL38756 | — | — | 1 | 5.66 |
| CHEMBL367128 | — | — | 1 | 5.48 |
| CHEMBL291280 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14 | CARBACHOL | EC50 | = | 102.33 | nM | 6.99 |
| CHEMBL38756 | — | EC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL367128 | — | EC50 | = | 3311.31 | nM | 5.48 |
| CHEMBL291280 | — | EC50 | = | 19952.62 | nM | 4.70 |