Assay Detail
Functional
CHEMBL696078
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Tested for the ability to inhibit spontaneous tone in guinea pig trachealis by 50%, activity expresses as negative logarithm of molar concentration
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachealis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N,N-disubstituted benzopyran-4-(N-cyano)carboxamidines, cromakalim analogs with selective activity for guinea pig trachealis
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.49 | 7.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13571 | — | — | 1 | 7.63 |
| CHEMBL269157 | — | — | 1 | 7.29 |
| CHEMBL275973 | — | — | 1 | 6.77 |
| CHEMBL275243 | — | — | 1 | 6.75 |
| CHEMBL13613 | — | — | 1 | 6.19 |
| CHEMBL11684 | (-)-CROMAKALIM | — | 1 | 6.07 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 5.80 |
| CHEMBL1563246 | — | — | 1 | 5.39 |
| CHEMBL263879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13571 | — | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL269157 | — | EC50 | = | 51.29 | nM | 7.29 |
| CHEMBL275973 | — | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL275243 | — | EC50 | = | 177.83 | nM | 6.75 |
| CHEMBL13613 | — | EC50 | = | 645.65 | nM | 6.19 |
| CHEMBL11684 | (-)-CROMAKALIM | EC50 | = | 851.14 | nM | 6.07 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL1563246 | — | EC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL263879 | — | EC50 | < | 31622.78 | nM | - |