Assay Detail
Functional
CHEMBL696131
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity of compound against VEGF induced cell proliferation
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.30 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148744 | — | — | 1 | 7.40 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 7.40 |
| CHEMBL147112 | — | — | 1 | 7.40 |
| CHEMBL89363 | — | — | 1 | 7.30 |
| CHEMBL357803 | — | — | 1 | 7.16 |
| CHEMBL147761 | — | — | 1 | 7.00 |
| CHEMBL148514 | — | — | 1 | 6.75 |
| CHEMBL344319 | — | — | 1 | 6.40 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 6.39 |
| CHEMBL443296 | — | — | 1 | 6.34 |
| CHEMBL450622 | — | — | 1 | 6.21 |
| CHEMBL356245 | — | — | 1 | 6.17 |
| CHEMBL347074 | — | — | 1 | 6.09 |
| CHEMBL358728 | — | — | 1 | 6.00 |
| CHEMBL149243 | — | — | 1 | 5.92 |
| CHEMBL148984 | — | — | 1 | 5.75 |
| CHEMBL146694 | — | — | 1 | 5.52 |
| CHEMBL150151 | — | — | 1 | 5.38 |
| CHEMBL149201 | — | — | 1 | 5.00 |
| CHEMBL150177 | — | — | 1 | 4.37 |
| CHEMBL149073 | — | — | 1 | - |
| CHEMBL146697 | — | — | 1 | - |
| CHEMBL435227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148744 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL147112 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL89363 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL357803 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL147761 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL148514 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL344319 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL443296 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL450622 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL356245 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL347074 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL358728 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL149243 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL148984 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL146694 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL150151 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL149201 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL150177 | — | IC50 | = | 42800.0 | nM | 4.37 |
| CHEMBL149073 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL146697 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL435227 | — | IC50 | > | 50000.0 | nM | - |