Compound Detail
CHEMBL443296
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Basic Information
| ChEMBL ID | CHEMBL443296 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OYFXUFAPLNTDRA-BKUYFWCQSA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
416.5
MW (Da)
4.90
ALogP
3
HBA
3
HBD
91.4
PSA (Ų)
0.48
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 6.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.57 | 5.96 | 270.0 | 2 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.34 | 6.17 | 460.0 | 2 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 5.62 | 5.285 | 2380.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 270.0 | nM | 6.57 | Inhibitory activity of compound against FGF induced cell proliferation | 10602697 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 460.0 | nM | 6.34 | Inhibitory activity of compound against VEGF induced cell proliferation | 10602697 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1000.0 | nM | 6.0 | Inhibitory activity against Vascular endothelial growth factor receptor 2 | 10602697 |
| Platelet-derived growth factor receptor beta | IC50 | = | 2380.0 | nM | 5.62 | Inhibitory activity against Platelet-derived growth factor receptor beta | 10602697 |
| Fibroblast growth factor receptor 1 | IC50 | = | 4500.0 | nM | 5.35 | Inhibitory activity against Fibroblast growth factor receptor 1 | 10602697 |
| Platelet-derived growth factor receptor beta | IC50 | = | 11300.0 | nM | 4.95 | Inhibitory activity of compound against PDGF induced cell proliferation | 10602697 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10602697 | 10.1021/jm9904295 | Vascular endothelial growth factor receptor 2 | 2 |
| 10602697 | 10.1021/jm9904295 | Fibroblast growth factor receptor 1 | 2 |
| 10602697 | 10.1021/jm9904295 | Platelet-derived growth factor receptor beta | 2 |
| 10602697 | 10.1021/jm9904295 | Epidermal growth factor receptor | 2 |
Data from ChEMBL 36 via Core Engine