Assay Detail
Binding
CHEMBL816967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Vascular endothelial growth factor receptor 2
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.18 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89363 | — | — | 1 | 7.70 |
| CHEMBL149073 | — | — | 1 | 7.16 |
| CHEMBL148514 | — | — | 1 | 7.05 |
| CHEMBL149201 | — | — | 1 | 6.85 |
| CHEMBL147761 | — | — | 1 | 6.70 |
| CHEMBL435227 | — | — | 1 | 6.62 |
| CHEMBL347074 | — | — | 1 | 6.52 |
| CHEMBL358728 | — | — | 1 | 6.52 |
| CHEMBL148744 | — | — | 1 | 6.46 |
| CHEMBL148984 | — | — | 1 | 6.35 |
| CHEMBL150151 | — | — | 1 | 6.28 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 6.16 |
| CHEMBL146697 | — | — | 1 | 6.04 |
| CHEMBL443296 | — | — | 1 | 6.00 |
| CHEMBL150177 | — | — | 1 | 5.90 |
| CHEMBL149243 | — | — | 1 | 5.87 |
| CHEMBL147112 | — | — | 1 | 5.83 |
| CHEMBL357803 | — | — | 1 | 5.76 |
| CHEMBL344319 | — | — | 1 | 5.67 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 5.61 |
| CHEMBL146694 | — | — | 1 | 5.36 |
| CHEMBL356245 | — | — | 1 | 5.08 |
| CHEMBL450622 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89363 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL149073 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL148514 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL149201 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL147761 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL435227 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL347074 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL358728 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL148744 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL148984 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL150151 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL146697 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL443296 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL150177 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL149243 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL147112 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL357803 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL344319 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL146694 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL356245 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL450622 | — | IC50 | = | 28300.0 | nM | 4.55 |