Compound Detail
CHEMBL150177
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Basic Information
| ChEMBL ID | CHEMBL150177 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NCORNUPANAVMRQ-ZSOIEALJSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
389.4
MW (Da)
1.79
ALogP
4
HBA
4
HBD
142.3
PSA (Ų)
0.58
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.55 | 6.55 | 280.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.9 | 5.135 | 1260.0 | 2 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 5.82 | 5.82 | 1530.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 4.07 | 4.07 | 84800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 280.0 | nM | 6.55 | Inhibitory activity against Fibroblast growth factor receptor 1 | 10602697 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1260.0 | nM | 5.9 | Inhibitory activity against Vascular endothelial growth factor receptor 2 | 10602697 |
| Platelet-derived growth factor receptor beta | IC50 | = | 1530.0 | nM | 5.82 | Inhibitory activity against Platelet-derived growth factor receptor beta | 10602697 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 42800.0 | nM | 4.37 | Inhibitory activity of compound against VEGF induced cell proliferation | 10602697 |
| Epidermal growth factor receptor | IC50 | = | 84800.0 | nM | 4.07 | Inhibitory activity against Epidermal growth factor receptor | 10602697 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10602697 | 10.1021/jm9904295 | Vascular endothelial growth factor receptor 2 | 2 |
| 10602697 | 10.1021/jm9904295 | Fibroblast growth factor receptor 1 | 2 |
| 10602697 | 10.1021/jm9904295 | Platelet-derived growth factor receptor beta | 2 |
| 10602697 | 10.1021/jm9904295 | Epidermal growth factor receptor | 2 |
Data from ChEMBL 36 via Core Engine