Assay Detail
Binding
CHEMBL763441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Platelet-derived growth factor receptor beta
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.24 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149201 | — | — | 1 | 8.00 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 7.22 |
| CHEMBL357803 | — | — | 1 | 7.22 |
| CHEMBL358728 | — | — | 1 | 7.00 |
| CHEMBL149243 | — | — | 1 | 6.85 |
| CHEMBL344319 | — | — | 1 | 6.85 |
| CHEMBL347074 | — | — | 1 | 6.80 |
| CHEMBL148514 | — | — | 1 | 6.77 |
| CHEMBL450622 | — | — | 1 | 6.35 |
| CHEMBL89363 | — | — | 1 | 6.29 |
| CHEMBL356245 | — | — | 1 | 6.26 |
| CHEMBL148744 | — | — | 1 | 6.21 |
| CHEMBL150151 | — | — | 1 | 6.00 |
| CHEMBL149073 | — | — | 1 | 5.92 |
| CHEMBL147112 | — | — | 1 | 5.85 |
| CHEMBL150177 | — | — | 1 | 5.82 |
| CHEMBL147761 | — | — | 1 | 5.68 |
| CHEMBL146694 | — | — | 1 | 5.65 |
| CHEMBL443296 | — | — | 1 | 5.62 |
| CHEMBL148984 | — | — | 1 | 5.51 |
| CHEMBL435227 | — | — | 1 | 5.38 |
| CHEMBL146697 | — | — | 1 | 5.22 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149201 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL357803 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL358728 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL149243 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL344319 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL347074 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL148514 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL450622 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL89363 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL356245 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL148744 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL150151 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL149073 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL147112 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL150177 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL147761 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL146694 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL443296 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL148984 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL435227 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL146697 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 10500.0 | nM | 4.98 |