Compound Detail
CHEMBL148744
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Basic Information
| ChEMBL ID | CHEMBL148744 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MLCYRSPCPRZKNI-QPEQYQDCSA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
375.2
MW (Da)
3.60
ALogP
2
HBA
3
HBD
82.2
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.4 | 6.93 | 40.0 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.1 | 6.705 | 80.0 | 2 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 6.21 | 5.69 | 620.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 40.0 | nM | 7.4 | Inhibitory activity of compound against VEGF induced cell proliferation | 10602697 |
| Fibroblast growth factor receptor 1 | IC50 | = | 80.0 | nM | 7.1 | Inhibitory activity against Fibroblast growth factor receptor 1 | 10602697 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 350.0 | nM | 6.46 | Inhibitory activity against Vascular endothelial growth factor receptor 2 | 10602697 |
| Fibroblast growth factor receptor 1 | IC50 | = | 490.0 | nM | 6.31 | Inhibitory activity of compound against FGF induced cell proliferation | 10602697 |
| Platelet-derived growth factor receptor beta | IC50 | = | 620.0 | nM | 6.21 | Inhibitory activity against Platelet-derived growth factor receptor beta | 10602697 |
| Platelet-derived growth factor receptor beta | IC50 | = | 6700.0 | nM | 5.17 | Inhibitory activity of compound against PDGF induced cell proliferation | 10602697 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10602697 | 10.1021/jm9904295 | Vascular endothelial growth factor receptor 2 | 2 |
| 10602697 | 10.1021/jm9904295 | Fibroblast growth factor receptor 1 | 2 |
| 10602697 | 10.1021/jm9904295 | Platelet-derived growth factor receptor beta | 2 |
| 10602697 | 10.1021/jm9904295 | Epidermal growth factor receptor | 2 |
Data from ChEMBL 36 via Core Engine