Assay Detail
Binding
CHEMBL678671
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Fibroblast growth factor receptor 1
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.96 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89363 | — | — | 1 | 7.52 |
| CHEMBL147761 | — | — | 1 | 7.52 |
| CHEMBL148744 | — | — | 1 | 7.10 |
| CHEMBL149073 | — | — | 1 | 6.55 |
| CHEMBL150177 | — | — | 1 | 6.55 |
| CHEMBL148514 | — | — | 1 | 6.44 |
| CHEMBL146697 | — | — | 1 | 6.34 |
| CHEMBL435227 | — | — | 1 | 6.11 |
| CHEMBL347074 | — | — | 1 | 5.98 |
| CHEMBL450622 | — | — | 1 | 5.92 |
| CHEMBL358728 | — | — | 1 | 5.85 |
| CHEMBL148984 | — | — | 1 | 5.81 |
| CHEMBL357803 | — | — | 1 | 5.69 |
| CHEMBL147112 | — | — | 1 | 5.67 |
| CHEMBL149201 | — | — | 1 | 5.64 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 5.52 |
| CHEMBL344319 | — | — | 1 | 5.43 |
| CHEMBL149243 | — | — | 1 | 5.41 |
| CHEMBL443296 | — | — | 1 | 5.35 |
| CHEMBL356245 | — | — | 1 | 5.27 |
| CHEMBL150151 | — | — | 1 | 5.24 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 5.15 |
| CHEMBL146694 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89363 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL147761 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL148744 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL149073 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL150177 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL148514 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL146697 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL435227 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL347074 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL450622 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL358728 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL148984 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL357803 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL147112 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL149201 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL344319 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL149243 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL443296 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL356245 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL150151 | — | IC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 7080.0 | nM | 5.15 |
| CHEMBL146694 | — | IC50 | = | 7330.0 | nM | 5.13 |