Assay Detail
Functional
CHEMBL871982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity of compound against PDGF induced cell proliferation
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.60 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149201 | — | — | 1 | 6.96 |
| CHEMBL347074 | — | — | 1 | 6.82 |
| CHEMBL148514 | — | — | 1 | 6.75 |
| CHEMBL358728 | — | — | 1 | 6.64 |
| CHEMBL147112 | — | — | 1 | 6.19 |
| CHEMBL150151 | — | — | 1 | 6.17 |
| CHEMBL146694 | — | — | 1 | 6.03 |
| CHEMBL149243 | — | — | 1 | 5.85 |
| CHEMBL356245 | — | — | 1 | 5.63 |
| CHEMBL148984 | — | — | 1 | 5.56 |
| CHEMBL357803 | — | — | 1 | 5.44 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 5.34 |
| CHEMBL148744 | — | — | 1 | 5.17 |
| CHEMBL450622 | — | — | 1 | 5.08 |
| CHEMBL443296 | — | — | 1 | 4.95 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 4.78 |
| CHEMBL89363 | — | — | 1 | 4.55 |
| CHEMBL147761 | — | — | 1 | 4.33 |
| CHEMBL344319 | — | — | 1 | 4.23 |
| CHEMBL149073 | — | — | 1 | - |
| CHEMBL146697 | — | — | 1 | - |
| CHEMBL150177 | — | — | 1 | - |
| CHEMBL435227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149201 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL347074 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL148514 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL358728 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL147112 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL150151 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL146694 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL149243 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL356245 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL148984 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL357803 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL148744 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL450622 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL443296 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL89363 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL147761 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL344319 | — | IC50 | = | 58400.0 | nM | 4.23 |
| CHEMBL149073 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL146697 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL150177 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL435227 | — | IC50 | > | 50000.0 | nM | - |