Assay Detail
Functional
CHEMBL700001
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound is evaluated for inhibitory effect on the generation of Leukotriene B4 (LTB4) from human neutrophils
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.68 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60987 | — | — | 1 | 6.82 |
| CHEMBL432337 | — | — | 1 | 6.82 |
| CHEMBL12594 | E-5110 | — | 1 | 6.60 |
| CHEMBL62143 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60987 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL432337 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL12594 | E-5110 | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL62143 | — | IC50 | = | 350.0 | nM | 6.46 |