Compound Detail
CHEMBL62143
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Basic Information
| ChEMBL ID | CHEMBL62143 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WFVLNIHBLHNNAK-XNTDXEJSSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
343.5
MW (Da)
4.15
ALogP
3
HBA
1
HBD
57.6
PSA (Ų)
0.78
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| Homo sapiens CHEMBL372 | IC50 | 6.46 | 6.46 | 350.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | IC50 | = | 200.0 | nM | 6.7 | Compound is evaluated for inhibitory effect on the generation of Prostaglandin E... | 3118023 |
| Homo sapiens | IC50 | = | 350.0 | nM | 6.46 | Compound is evaluated for inhibitory effect on the generation of Leukotriene B4 ... | 3118023 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3118023 | 10.1021/jm00394a011 | Rattus norvegicus | 8 |
| 3118023 | 10.1021/jm00394a011 | Homo sapiens | 1 |
Data from ChEMBL 36 via Core Engine