Assay Detail
Functional
CHEMBL782879
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Compound is evaluated for inhibitory effect on the generation of Prostaglandin E2 (PGE2) from rat synovial cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.72 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12594 | E-5110 | — | 1 | 7.52 |
| CHEMBL432337 | — | — | 1 | 7.52 |
| CHEMBL60987 | — | — | 1 | 7.30 |
| CHEMBL527 | PIROXICAM | 4.0 | 1 | 7.00 |
| CHEMBL62143 | — | — | 1 | 6.70 |
| CHEMBL60315 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12594 | E-5110 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL432337 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL60987 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL527 | PIROXICAM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL62143 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL60315 | — | IC50 | = | 50000.0 | nM | 4.30 |