Assay Detail
Functional
CHEMBL706884
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Anti-proliferative activity was evaluated by its ability to inhibit proliferation of MDCK-f3 (Madin-Darby canine kidney f3) cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New indene-derivatives with anti-proliferative properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.21 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353128 | — | — | 1 | 4.30 |
| CHEMBL351496 | — | — | 1 | 4.22 |
| CHEMBL163514 | — | — | 1 | 4.10 |
| CHEMBL163161 | — | — | 1 | - |
| CHEMBL18797 | SULINDAC SULFIDE | -1.0 | 1 | - |
| CHEMBL163333 | — | — | 1 | - |
| CHEMBL15770 | SULINDAC | 4.0 | 1 | - |
| CHEMBL163404 | — | — | 1 | - |
| CHEMBL434291 | — | — | 1 | - |
| CHEMBL159846 | — | — | 1 | - |
| CHEMBL352898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353128 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL351496 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL163514 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL163161 | — | IC50 | = | 310000.0 | nM | - |
| CHEMBL18797 | SULINDAC SULFIDE | IC50 | = | 200000.0 | nM | - |
| CHEMBL163333 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL15770 | SULINDAC | IC50 | = | 320000.0 | nM | - |
| CHEMBL163404 | — | IC50 | = | 360000.0 | nM | - |
| CHEMBL434291 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL159846 | — | IC50 | = | 310000.0 | nM | - |
| CHEMBL352898 | — | IC50 | = | 120000.0 | nM | - |