Assay Detail
Functional
CHEMBL708366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro T-cell immunosuppressive activity in the mouse mixed lymphocyte reaction (MLR)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.47 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.22 |
| CHEMBL432488 | — | — | 1 | 5.18 |
| CHEMBL59800 | — | — | 1 | 5.17 |
| CHEMBL960 | LEFLUNOMIDE | 4.0 | 1 | 4.94 |
| CHEMBL303587 | — | — | 1 | 4.70 |
| CHEMBL60338 | — | — | 1 | 4.63 |
| CHEMBL59799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL432488 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL59800 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL303587 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL60338 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL59799 | — | IC50 | > | 22400.0 | nM | - |