Assay Detail
Functional
CHEMBL708534
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Antiviral activity against influenza A H2N2(A2 japan/305/57) in MDCK cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Spiro[pyrrolidine-2,2'-adamantanes]: synthesis, anti-influenza virus activity and conformational properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.51 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 5.96 |
| CHEMBL295380 | — | — | 1 | 5.75 |
| CHEMBL45179 | — | — | 1 | 5.60 |
| CHEMBL296878 | — | — | 1 | 5.57 |
| CHEMBL45505 | — | — | 1 | 5.54 |
| CHEMBL44782 | — | — | 1 | 5.48 |
| CHEMBL46178 | — | — | 1 | 5.48 |
| CHEMBL47530 | — | — | 1 | 5.43 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.43 |
| CHEMBL298444 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL660 | AMANTADINE | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL295380 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL45179 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL296878 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL45505 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL44782 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL46178 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL47530 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL298444 | — | EC50 | = | 12500.0 | nM | 4.90 |