Assay Detail
Functional
CHEMBL709608
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Tested in vitro for anticancer activity against LNCaP cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.53 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 5.92 |
| CHEMBL38700 | ELVUCITABINE | 2.0 | 1 | 4.26 |
| CHEMBL169267 | — | — | 1 | 4.24 |
| CHEMBL355426 | — | — | 1 | 4.17 |
| CHEMBL2368322 | — | — | 1 | 4.07 |
| CHEMBL2368321 | — | — | 1 | - |
| CHEMBL354904 | — | — | 1 | - |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
| CHEMBL355081 | — | — | 1 | - |
| CHEMBL366529 | — | — | 1 | - |
| CHEMBL169434 | — | — | 1 | - |
| CHEMBL169277 | — | — | 1 | - |
| CHEMBL171286 | — | — | 1 | - |
| CHEMBL109831 | DEXELVUCITABINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL38700 | ELVUCITABINE | IC50 | = | 55200.0 | nM | 4.26 |
| CHEMBL169267 | — | IC50 | = | 57200.0 | nM | 4.24 |
| CHEMBL355426 | — | IC50 | = | 67800.0 | nM | 4.17 |
| CHEMBL2368322 | — | IC50 | = | 85800.0 | nM | 4.07 |
| CHEMBL2368321 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL354904 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL185 | FLUOROURACIL | IC50 | > | 100000.0 | nM | - |
| CHEMBL355081 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL366529 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL169434 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL169277 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL171286 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109831 | DEXELVUCITABINE | IC50 | > | 100000.0 | nM | - |