Assay Detail
Binding
CHEMBL710517
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Inhibition of [3H]LTD4 binding to LTD4 receptor in guinea pig lung membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.38 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282524 | — | — | 1 | 6.19 |
| CHEMBL283455 | — | — | 1 | 5.82 |
| CHEMBL28797 | — | — | 1 | 5.17 |
| CHEMBL8747 | REV-5901 | — | 1 | 5.10 |
| CHEMBL442150 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282524 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL283455 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL28797 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL8747 | REV-5901 | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL442150 | — | Ki | = | 24000.0 | nM | 4.62 |