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Assay Detail

CHEMBL711784

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vivo inhibition of leutenising hormone in rats.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Lutropin-choriogonadotropic hormone receptor (CHEMBL2456)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Active reduced-size hexapeptide analogues of luteinizing hormone-releasing hormone.
Haviv F, Palabrica CA, Bush EN, Diaz G, Johnson ES, Love S, Greer J.
J Med Chem (1989) 32 : 2340 -2344
PubMed 2552116 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 21 7.65 9.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL412984 1 9.44
CHEMBL275694 1 8.74
CHEMBL264298 1 8.52
CHEMBL265413 1 8.50
CHEMBL274609 1 8.44
CHEMBL275709 1 8.20
CHEMBL2369807 1 8.18
CHEMBL413887 1 8.07
CHEMBL415109 1 7.98
CHEMBL412573 1 7.89
CHEMBL2369800 1 7.83
CHEMBL2369798 1 7.80
CHEMBL429543 1 7.60
CHEMBL411175 1 7.49
CHEMBL2369787 1 7.22
CHEMBL386525 1 7.10
CHEMBL2369813 1 6.60
CHEMBL2369793 1 6.46
CHEMBL2369808 1 6.44
CHEMBL2369799 1 6.08
CHEMBL2369806 1 6.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL412984 Kd = 0.3631 nM 9.44
CHEMBL275694 Kd = 1.82 nM 8.74
CHEMBL264298 Kd = 3.02 nM 8.52
CHEMBL265413 Kd = 3.162 nM 8.50
CHEMBL274609 Kd = 3.631 nM 8.44
CHEMBL275709 Kd = 6.31 nM 8.20
CHEMBL2369807 Kd = 6.607 nM 8.18
CHEMBL413887 Kd = 8.511 nM 8.07
CHEMBL415109 Kd = 10.47 nM 7.98
CHEMBL412573 Kd = 12.88 nM 7.89
CHEMBL2369800 Kd = 14.79 nM 7.83
CHEMBL2369798 Kd = 15.85 nM 7.80
CHEMBL429543 Kd = 25.12 nM 7.60
CHEMBL411175 Kd = 32.36 nM 7.49
CHEMBL2369787 Kd = 60.26 nM 7.22
CHEMBL386525 Kd = 79.43 nM 7.10
CHEMBL2369813 Kd = 251.19 nM 6.60
CHEMBL2369793 Kd = 346.74 nM 6.46
CHEMBL2369808 Kd = 363.08 nM 6.44
CHEMBL2369799 Kd = 831.76 nM 6.08
CHEMBL2369806 Kd = 851.14 nM 6.07