Assay Detail
Binding
CHEMBL714710
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Binding affinity against ovine pars tuberalis melatonin receptor using 2-[125I]- melatonin radioligand binding assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of conformationally restricted tricyclic analogs of the hormone melatonin
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.76 | 10.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 10.04 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 10.00 |
| CHEMBL11356 | — | — | 1 | 9.86 |
| CHEMBL274358 | — | — | 1 | 9.67 |
| CHEMBL11404 | — | — | 1 | 9.11 |
| CHEMBL11328 | — | — | 1 | 8.21 |
| CHEMBL11416 | — | — | 1 | 7.86 |
| CHEMBL11148 | — | — | 1 | 7.21 |
| CHEMBL10816 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.0915 | nM | 10.04 |
| CHEMBL10878 | AGOMELATINE | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL11356 | — | Ki | = | 0.137 | nM | 9.86 |
| CHEMBL274358 | — | Ki | = | 0.216 | nM | 9.67 |
| CHEMBL11404 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL11328 | — | Ki | = | 6.17 | nM | 8.21 |
| CHEMBL11416 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL11148 | — | Ki | = | 62.2 | nM | 7.21 |
| CHEMBL10816 | — | Ki | = | 130.0 | nM | 6.89 |