Assay Detail
Functional
CHEMBL719973
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In vitro inhibitory concentration against mice infected with Trypanosoma brucei pentamidine-sensitive strain (EATRO Lab 110).
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Trypanocidal activity of conformationally restricted pentamidine congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.35 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 9.10 |
| CHEMBL269032 | — | — | 1 | 8.67 |
| CHEMBL25526 | — | — | 1 | 8.03 |
| CHEMBL8892 | — | — | 1 | 7.73 |
| CHEMBL9185 | — | — | 1 | 7.56 |
| CHEMBL9126 | — | — | 1 | 7.24 |
| CHEMBL9391 | — | — | 1 | 7.16 |
| CHEMBL267154 | — | — | 1 | 7.15 |
| CHEMBL9516 | — | — | 1 | 7.07 |
| CHEMBL9479 | — | — | 1 | 6.77 |
| CHEMBL9053 | — | — | 1 | 6.75 |
| CHEMBL276449 | — | — | 1 | 6.27 |
| CHEMBL9025 | — | — | 1 | 6.06 |
| CHEMBL2311124 | — | — | 1 | - |
| CHEMBL9121 | — | — | 1 | - |
| CHEMBL9531 | — | — | 1 | - |
| CHEMBL266808 | — | — | 1 | - |
| CHEMBL9490 | — | — | 1 | - |
| CHEMBL9341 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL269032 | — | IC50 | = | 2.15 | nM | 8.67 |
| CHEMBL25526 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL8892 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL9185 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL9126 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL9391 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL267154 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL9516 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL9479 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL9053 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL276449 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL9025 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL2311124 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL9121 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL9531 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL266808 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL9490 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL9341 | — | IC50 | > | 1000.0 | nM | - |