Compound Detail
CHEMBL267154
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Basic Information
| ChEMBL ID | CHEMBL267154 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YYVFIGGEWQGLMO-MNDPQUGUSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
385.5
MW (Da)
3.07
ALogP
5
HBA
2
HBD
52.0
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei CHEMBL612849 | IC50 | 7.15 | 7.1033 | 71.0 | 3 |
| Mus musculus CHEMBL375 | IC50 | 7.06 | 7.06 | 88.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei | IC50 | = | 71.0 | nM | 7.15 | In vitro inhibitory concentration against mice infected with Trypanosoma brucei ... | 12620080 |
| Trypanosoma brucei | IC50 | = | 84.0 | nM | 7.08 | In vitro inhibitory concentration against mice infected with Trypanosoma brucei ... | 12620080 |
| Trypanosoma brucei | IC50 | = | 84.0 | nM | 7.08 | In vitro inhibitory concentration against mouse infected with Trypanosoma brucei... | 12620080 |
| Mus musculus | IC50 | = | 88.0 | nM | 7.06 | In vitro inhibitory concentration against mouse infected with Trypanosoma brucei... | 12620080 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12620080 | 10.1021/jm020375q | Trypanosoma brucei | 3 |
| 12620080 | 10.1021/jm020375q | Mus musculus | 1 |
| 12620080 | 10.1021/jm020375q | Calf thymus DNA | 1 |
| 12620080 | 10.1021/jm020375q | Nucleic Acid | 1 |
Data from ChEMBL 36 via Core Engine