Assay Detail
Functional
CHEMBL735753
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Opioid agonist potencies was determined by mouse vas deferens (MVD)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hybrid bivalent ligands with opiate and enkephalin pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.28 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8234 | ENKEPHALIN | — | 1 | 8.07 |
| CHEMBL607320 | — | — | 1 | 7.57 |
| CHEMBL607321 | — | — | 1 | 7.32 |
| CHEMBL60377 | — | — | 1 | 7.21 |
| CHEMBL607322 | — | — | 1 | 7.11 |
| CHEMBL294134 | — | — | 1 | 6.91 |
| CHEMBL607319 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8234 | ENKEPHALIN | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL607320 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL607321 | — | IC50 | = | 47.7 | nM | 7.32 |
| CHEMBL60377 | — | IC50 | = | 61.8 | nM | 7.21 |
| CHEMBL607322 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL294134 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL607319 | — | IC50 | = | 166.0 | nM | 6.78 |