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Assay Detail

CHEMBL739443

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity against nitric oxide production in LPS-activated mouse peritoneal macrophages
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Confidence 1 — Organism
Curated By Expert

Target

Mus musculus (CHEMBL375)
Type ORGANISM
Organism Mus musculus

Publication

Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages.
Matsuda H, Kageura T, Morikawa T, Toguchida I, Harima S, Yoshikawa M.
Bioorg Med Chem Lett (2000) 10 : 323 -327
PubMed 10714491 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 4.57 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL105278 GUANIDINOETHYLDISULFIDE 1 5.85
CHEMBL419924 1 5.24
CHEMBL113598 1 4.96
CHEMBL320571 1 4.89
CHEMBL296411 TRISMETHOXYRESVERATROL 1 4.66
CHEMBL69863 PICEATANNOL 1 4.64
CHEMBL113074 1 4.57
CHEMBL256147 TILARGININE 3.0 1 4.55
CHEMBL44509 (E)-3,4,3',5'-TETRAMETHOXYSTILBENE 1 4.55
CHEMBL329520 1 4.50
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER 1 4.40
CHEMBL113029 1 4.32
CHEMBL110154 1 4.31
CHEMBL110370 1 4.20
CHEMBL288114 GALLIC ACID 2.0 1 4.20
CHEMBL165 RESVERATROL 3.0 1 4.17
CHEMBL109330 1 4.16
CHEMBL111234 DIHYDRORESVERATROL 1 4.12
CHEMBL109702 1 -
CHEMBL440895 1 -
CHEMBL113028 1 -
CHEMBL111185 1 -
CHEMBL41092 CHRYSOPHANOL 1 -
CHEMBL113536 1 -
CHEMBL109609 1 -
CHEMBL443804 PULMATIN 1 -
CHEMBL325769 1 -
CHEMBL112709 CHRYSOPHANEIN 1 -
CHEMBL109266 RHAPONTIN 1 -
CHEMBL113339 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL105278 GUANIDINOETHYLDISULFIDE IC50 = 1400.0 nM 5.85
CHEMBL419924 IC50 = 5800.0 nM 5.24
CHEMBL113598 IC50 = 11000.0 nM 4.96
CHEMBL320571 IC50 = 13000.0 nM 4.89
CHEMBL296411 TRISMETHOXYRESVERATROL IC50 = 22000.0 nM 4.66
CHEMBL69863 PICEATANNOL IC50 = 23000.0 nM 4.64
CHEMBL113074 IC50 = 27000.0 nM 4.57
CHEMBL256147 TILARGININE IC50 = 28000.0 nM 4.55
CHEMBL44509 (E)-3,4,3',5'-TETRAMETHOXYSTILBENE IC50 = 28000.0 nM 4.55
CHEMBL329520 IC50 = 32000.0 nM 4.50
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER IC50 = 40000.0 nM 4.40
CHEMBL113029 IC50 = 48000.0 nM 4.32
CHEMBL110154 IC50 = 49000.0 nM 4.31
CHEMBL110370 IC50 = 63000.0 nM 4.20
CHEMBL288114 GALLIC ACID IC50 = 63000.0 nM 4.20
CHEMBL165 RESVERATROL IC50 = 68000.0 nM 4.17
CHEMBL109330 IC50 = 69000.0 nM 4.16
CHEMBL111234 DIHYDRORESVERATROL IC50 = 76000.0 nM 4.12
CHEMBL109702 IC50 > 100000.0 nM -
CHEMBL440895 IC50 > 100000.0 nM -
CHEMBL113028 IC50 > 100000.0 nM -
CHEMBL111185 IC50 > 100000.0 nM -
CHEMBL41092 CHRYSOPHANOL IC50 > 100000.0 nM -
CHEMBL113536 IC50 > 100000.0 nM -
CHEMBL109609 IC50 > 100000.0 nM -
CHEMBL443804 PULMATIN IC50 > 100000.0 nM -
CHEMBL325769 IC50 > 100000.0 nM -
CHEMBL112709 CHRYSOPHANEIN IC50 > 100000.0 nM -
CHEMBL109266 RHAPONTIN IC50 > 100000.0 nM -
CHEMBL113339 IC50 > 100000.0 nM -
CHEMBL109802 IC50 > 100000.0 nM -