Assay Detail
Functional
CHEMBL740145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of electrically evoked contractions of the mouse vas deferens (MVD)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.15 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15100 | — | — | 1 | 8.30 |
| CHEMBL8234 | ENKEPHALIN | — | 1 | 7.94 |
| CHEMBL14887 | — | — | 1 | 7.79 |
| CHEMBL278891 | — | — | 1 | 7.52 |
| CHEMBL280264 | — | — | 1 | 7.49 |
| CHEMBL2370199 | — | — | 1 | 7.16 |
| CHEMBL278889 | — | — | 1 | 6.00 |
| CHEMBL2370207 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15100 | — | IC50 | = | 4.98 | nM | 8.30 |
| CHEMBL8234 | ENKEPHALIN | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL14887 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL278891 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL280264 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL2370199 | — | IC50 | = | 69.9 | nM | 7.16 |
| CHEMBL278889 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2370207 | — | IC50 | = | 10000.0 | nM | 5.00 |